The present research was undertaken in order to measure the concentrations of heavy metals in tissues of the Scomberomorus commerson and Scomberomorus guttatus in Bushehr seaport. 20 samples of S. commerson and 20 samples of S. guttatus were cathed randomly from Bushehr seaport. After biometry of fish, the tissue samples were taken from muscles and liverand chemical digestion of the samples were carried out based on MOOPAM, and then levels of heavy metals in tissues were measured. Based on the results, there was a significant difference between the mean of Cu, Zn and Fe metals in the muscle and liver tissues of S. commerson and S. guttatus (P<0.05). A comparison between the research results and international standards revealed that the concentrations of the Cu and Zn heavy metals in the muscle and liver tissues of the S. commerson and S. guttatus in the study area were lower than the WHO, FAO, NHMRC, and UK (MAFF) approved standard levels. However, the concentration of Fe was higher than the FDA-approved level. Hence, these two species will not pose severe general health risks to human consumers.