This study was carried out to measure the concentrations of heavy metals Nickel and Cadmium in muscle tissues of two species of Scomberomorus commerson and Scomberomorus guttatus in Bushehr seaport during summer 2015. 20 samples of Scomberomorus commerson and 20 samples of Scomberomorus guttatus were caught completely at random from Bushehr seaport by the area native fishermen using a gillnet. After biometry of the samples, the muscle tissues of the samples were separated and chemical digestion of the samples was done, then Nickel and Cadmium accumulation levels in tissues were measured using Graphite furnace atomic absorption instrument (VARIAN AA 100). Based on the obtained results the mean concentrations of Nickel in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus were calculated 0.295 ± 0.074 and 0.320 ± 0.081 mg/kg dry weight respectively and showed that there were no significant differences (P>0.05). Moreover, based on the obtained results the mean concentrations of Cadmium in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus were calculated 0.105 ± 0.114 and 0.126 ± 0.166 mg/kg dry weight respectively and showed that there were no significant differences (P>0.05). The results of this study revealed that the Nickel and Cadmium metals concentration in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus in study station are lower than the levels permitted within the standards of World Health Organization (WHO), Food and Agricultural Organization (FAO), National Health and Medical Research Council (Australia) (NHMRC), Ministry of Agriculture, Forestry and Fisheries UK(MAFF) and Food and Drug Administration (FDA). So the use of these two species for human consumption from the perspective of public health will not create a problem.